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Discovery of protein factories may lead to novel agents for the treatment of cancer

For 10 years, Patrick Cramer and his colleagues at Ludwig-Maximilians-Universitaet (LMU) in Munich have probed the structure of RNA polymerase I, a crucial cog in the machinery of all cells. Now they unveil the full three-dimensional conformation of the enzyme – at atomic resolution. Actively growing cells must synthesize large amounts of protein, which in turn requires huge numbers of protein production plants, the so-called ribosomes. Ribosomes themselves consist of proteins mounted on a framework of ribosomal RNA…

Source: Medical News Today




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